Nuclear localization of the transcriptional activator NF-κB (nuclear factor κB) is controlled in
mammalian cells by three isoforms of NF-κB inhibitor protein: IκBα,-β, and-ɛ. Based on …

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by
sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A …

Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from
inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB …

The eukaryotic transcription factor nuclear factor-kappa B (NF-κB) participates in many parts
of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of …

IκB-α inhibits transcription factor NF-κB by retaining it in the cytoplasm. Various stimuli,
typically those associated with stress or pathogens, rapidly inactivate IκB-α. This liberates …

The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …

Nuclear factor kappa B (NF-κB)/Rel proteins are dimeric, sequence-specific transcription
factors involved in the activation of an exceptionally large number of genes in response to …

A large protein complex mediates the phosphorylation of the inhibitor of κB (IκB), which
results in the activation of nuclear factor κB (NF-κB). Two subunits of this complex, IκB kinase …

One of the most intensely studied regulators of gene expression is the transcription factor NF-
κB. NF-κB activates groups of genes in response to a wide array of extracellular factors …

Transcription factors of the NF-κB family are essential regulators of the inflammatory and
immune responses. The main'switch'in NF-κB activation is cytoplasmic and leads to the …