L-cysteine stimulates hydrogen sulfide synthesis in myocardium associated with attenuation of ischemia-reperfusion injury

DJ Elsey, RC Fowkes… - Journal of cardiovascular …, 2010 - journals.sagepub.com
Hydrogen sulfide (H 2S) is a biological mediator produced by enzyme-regulated pathways
from L-cysteine, which is a substrate for cystathionine-γ-lyase (CSE). In myocardium …

S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway

SC Chuah, PK Moore, YZ Zhu - American Journal of …, 2007 - journals.physiology.org
S-allylcysteine (SAC) is an organosulfur-containing compound derived from garlic. Studies
have shown that garlic is beneficial in the treatment of cardiovascular diseases. This study …

Hydrogen sulfide treatment improves post-infarct remodeling and long-term cardiac function in CSE knockout and wild-type mice

LJ Ellmers, EM Templeton, AP Pilbrow… - International journal of …, 2020 - mdpi.com
Hydrogen sulfide (H2S) is recognized as an endogenous gaseous signaling molecule
generated by cystathionine γ-lyase (CSE) in cardiovascular tissues. H2S up-regulation has …

Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury

Y Ji, Q Pang, G Xu, L Wang, J Wang, Y Zeng - European journal of …, 2008 - Elsevier
Hydrogen sulfide (H2S) is an endogenous gaseous mediator, produced by pyridoxal-5′-
phosphate-dependent enzymes cystathionine-β-synthase (CBS) and cystathionine-γ …

Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol

B Geng, L Chang, C Pan, Y Qi, J Zhao, Y Pang… - Biochemical and …, 2004 - Elsevier
Previous work has shown that the endogenous cystathionine γ-synthase (CSE)/hydrogen
sulfide (H2S) pathway participates in the regulation of cardiac contraction. We hypothesized …

Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

S Nakano, I Ishii, K Shinmura, K Tamaki… - Journal of Molecular …, 2015 - Springer
Elevated plasma homocysteine levels are considered an independent risk factor for
cardiovascular diseases. Experimental evidence has shown that hydrogen sulfide anion …

Attenuation of cardiac ischemia-reperfusion injury by sodium thiosulfate is partially dependent on the effect of cystathione beta synthase in the myocardium

S Kannan, SR Boovarahan, J Rengaraju… - Cell biochemistry and …, 2019 - Springer
Our early studies have shown that sodium thiosulfate (STS) treatment attenuated the
ischemia-reperfusion (IR)-induced injury in an isolated rat heart model by decreasing …

Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice

JW Calvert, M Elston, CK Nicholson, S Gundewar… - Circulation, 2010 - Am Heart Assoc
Background—Hydrogen sulfide (H2S) is an endogenous signaling molecule with potent
cytoprotective effects. The present study evaluated the therapeutic potential of H2S in …

Protective mechanisms of hydrogen sulfide in myocardial ischemia

Y Chen, F Zhang, J Yin, S Wu… - Journal of cellular …, 2020 - Wiley Online Library
Abstract Hydrogen sulfide (H2S), which has been identified as the third gaseous signaling
molecule after nitric oxide (NO) and carbon monoxide (CO), plays an important role in …

Hydrogen sulfide reduces regional myocardial ischemia injury through protection of mitochondrial function

YH Xie, N Zhang, LF Li, QZ Zhang… - Molecular …, 2014 - spandidos-publications.com
Hydrogen sulfide (H2S) is a signaling gasotransmitter, involved in various physiological and
pathological processes. H2S‑donating drugs have been tested to conjugate the beneficial …