Substance P (SP) is a neuropeptide associated with sensory innervation of lymphoid tissue
and a suspected modulator of lymphatic function in inflammation. Only a few studies have …

Background: Substance P (SP) is associated with lymphatic tissue and is a putative mediator
of inflammation. The lymph pump is one of the major" safety factors" preventing edema and …

Peptides released from peripheral nerve endings in mammals, including the tachykinin
substance P (SP) and vasoactive intestinal polypeptide (VIP), are potent mediators of …

Substance P (SP), one of the established neurotransmitters, evokes an immunoinflammatory
response involving leukocyte adhesion to venular endothelium and the degranulation of …

Substance P (SP) is a peptide found in the sensory nervous system which has multiple
biologic effects including stimulation of muscle contraction, pain nociception, immune cell …

Collecting lymphatic vessels share functional and biochemical characteristics with cardiac
muscle; thus, we hypothesized that the lymphatic vessel pump would exhibit behavior …

Substance P (SP), discovered by von Euler and Gaddum more than 50 years ago, is a
neuropeptide, comprised of eleven amino acids (cf. Fig. 1), with a wide distribution in the …

Peptidergic nerves in immune organs and lymphoid tissues of the lungs and gastrointestinal
tract end on or in close proximity to lymphocytes, mast cells and macrophages. Vasoactive …

The neuropeptide substance P modulates the activities of a number of different leukocytes
that characterize both acute and delayed inflammatory responses. Substance P may play a …

Immunohistochemistry for substance P (SP) in the rat thymus revealed fine varicose neural
profiles in specific regions of the thymus. Thymic SP innervation was abundant within the …