Until recently, our understanding of the functional neuroanatomy of the cholinergicbasal
forebrain (CBF) has been hindered by the lack of a lesioning technique that is truly selective …

The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped
subsequent research on the role of the basal forebrain in learning and memory. In particular …

The role of cholinergic basal forebrain (CBF) neurons in mnemonic behaviors was
investigated using the immunotoxin 192IgG-saporin. We assessed two routes of …

The basal forebrain cholinergic system, which innervates widespread cortical and limbic
structures, has traditionally been considered important for learning and memory. The use of …

Use of the selective immunotoxin; 192 IgG-saporin, is helping to elucidate the role of the
cholinergic system in cognition by overcoming the problems of interpretation associated with …

The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool
to study the implication of these neurons in cognition, an interest widely motivated by their …

Rationale. Excitotoxic lesions of the nucleus basalis magnocellularis (nbm) in rats produce
deficits in performance of the 5-choice serial reaction time (5CSRT) task, suggesting that …

Selective depletion of nerve growth factor receptor‐bearing neurons in the basal forebrain
cholinergic nuclei by the immunotoxin 192 IgG‐saporin offers a new and highly useful tool …

Abstract Male Long-Evans rats were given injections of either 192 IgG-saporin, an
apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) …

The elucidation of the functional role of the basal forebrain cholinergic system will require
access to a highly specific and efficient cholinergic neurotoxin. Recently, selective depletion …