Skin inflammation often evokes pruritus, which is the major subjective symptom in many
inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is …

In recent years, the published literature has suggested the key involvement of the cytokine
interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have …

Pruritus represents one of the most common symptoms in dermatology and general
medicine. Chronic pruritus severely impairs the quality of life of affected patients. During the …

BACKGROUND: IL-31 is a novel T-cell–derived cytokine that induces severe pruritus and
dermatitis in transgenic mice, and signals through a heterodimeric receptor composed of IL …

Background: Although the pathophysiology of pruritus has been extensively studied in
recent years, with many resultant advancements, management of pruritus is still enigmatic …

Abstract Interleukin 31 (IL-31) is a neurocytokine that stimulates sensory neurons involved in
pruritus. It contributes to skin barrier inflammation, dysfunction, and remodeling. As the …

Background: Atopic dermatitis, a chronic inflammatory disease, has a lifetime prevalence of
10–20%. Atopic dermatitis reduces quality of life, primarily due to pruritus. Interleukin-31 and …

Atopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin lesions
caused by skin barrier dysfunction and T helper (Th) 2 cell‐mediated immunity. Interleukin …

Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain
types of chronic urticaria, are associated with intensive pruritus. While histamine and …

Atopic dermatitis (AD), a pruritic, inflammatory chronic disease with multifactorial
pathogenesis, has been a therapeutic challenge. Novel target treatments aim to reduce not …