MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms
that are still poorly understood yet have important clinical implications. Oestrogen-receptor …

Cancer-specific alterations in DNA methylation are hallmarks of human malignancies;
however, the nature of the breast cancer epigenome and its effects on metastatic behavior …

The development of breast cancer metastasis is accompanied by dynamic transcriptome
changes and dramatic alterations in nuclear and chromatin structure. The basis of these …

Background We have previously identified genome-wide DNA methylation changes in a cell
line model of breast cancer metastasis. These complex epigenetic changes that we …

Epigenetic modifications introduce an additional layer of regulation that drastically expands
the instructional capability of the human genome. The regulatory consequences of DNA …

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to
orchestrate transcriptional networks to drive disease progression. In primary breast cancer …

Background Dysregulation of the epigenome is a common event in malignancy; however,
deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer …

RNA polymerase III transcription is pivotal in regulating cellular growth and frequently
deregulated in various cancers. MAF1 negatively regulates RNA polymerase III transcription …

Breast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how
these affect the transcriptome and which changes are linked to transformation or …

Background: There are currently no biomarkers for early breast cancer patient populations at
risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical …