Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label …
D Azzopardi, NJ Robertson, A Bainbridge… - The Lancet …, 2016 - thelancet.com
Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …
in death and disability, but additional therapies might provide further benefit. We assessed …
Xenon augmented hypothermia reduces early lactate/N‐acetylaspartate and cell death in perinatal asphyxia
S Faulkner, A Bainbridge, T Kato… - Annals of …, 2011 - Wiley Online Library
Objective: Additional treatments for therapeutic hypothermia are required to maximize
neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective …
neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective …
Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial
NJ Robertson, M Nakakeeto, C Hagmann, FM Cowan… - The Lancet, 2008 - thelancet.com
In 2005, the Lancet Neonatal Survival Series1 highlighted the fact that 4 million babies die in
the neonatal period; 99% of these deaths arise in low-income and middle-income countries …
the neonatal period; 99% of these deaths arise in low-income and middle-income countries …
Therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy–where to from here?
JO Davidson, G Wassink, LG Van den Heuij… - Frontiers in …, 2015 - frontiersin.org
Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …
births and is associated with a high risk of death or lifelong disability. Therapeutic …
Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial
Background Moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy
might improve survival and neurological outcomes at up to 18 months of age, although …
might improve survival and neurological outcomes at up to 18 months of age, although …
Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy
S Shankaran, AR Laptook… - … England Journal of …, 2005 - Mass Medical Soc
Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …
models. However, the safety and effectiveness of hypothermia in term infants with …
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia
D Ma, M Hossain, A Chow, M Arshad… - Annals of …, 2005 - Wiley Online Library
Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral
consequences. Although hypothermia may provide some modest benefit, the intervention …
consequences. Although hypothermia may provide some modest benefit, the intervention …
Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial
D Azzopardi, B Strohm, AD Edwards… - Archives of Disease in …, 2009 - fn.bmj.com
Background: This is a phase 4 study of infants registered with the UK TOBY Cooling
Register from December 2006 to February 2008. The registry was established on …
Register from December 2006 to February 2008. The registry was established on …
Cooling for newborns with hypoxic ischaemic encephalopathy
SE Jacobs, M Berg, R Hunt… - Cochrane database …, 2013 - cochranelibrary.com
Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …
Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
PD Gluckman, JS Wyatt, D Azzopardi, R Ballard… - The Lancet, 2005 - thelancet.com
Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …
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