Background Moderate cooling after birth asphyxia is associated with substantial reductions
in death and disability, but additional therapies might provide further benefit. We assessed …

Objective: Additional treatments for therapeutic hypothermia are required to maximize
neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective …

In 2005, the Lancet Neonatal Survival Series1 highlighted the fact that 4 million babies die in
the neonatal period; 99% of these deaths arise in low-income and middle-income countries …

Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …

Background Moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy
might improve survival and neurological outcomes at up to 18 months of age, although …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Perinatal asphyxia can result in neuronal injury with long‐term neurological and behavioral
consequences. Although hypothermia may provide some modest benefit, the intervention …

Background: This is a phase 4 study of infants registered with the UK TOBY Cooling
Register from December 2006 to February 2008. The registry was established on …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …