CPT I (outer membrane carnitine palmitoyltransferase I) is a crucial enzyme in myocardial
substrate selection. Two isoforms exist in the heart, the liver (L-) and muscle (M-) isoforms …

Heart carnitine palmitoyl transferase I (CPTI) is inhibited in vivo during endotoxaemia and in
vitro by peroxynitrite but the biochemical basis of this inhibition is not known. The aim of this …

Carnitine palmitoyltransferase I (CPT I) catalyzes the conversion of acyl-CoA to acylcarnitine
at the outer mitochondrial membrane and is a key enzyme in the control of long-chain fatty …

Fatty acids are the preferred substrate of ischemic, reperfused myocardium and may account
for the decreased cardiac efficiency during aerobic recovery. Neonatal cardiac myocytes in …

Carnitine palmitoyltransferase-I (CPT-I) is a major control point for fatty acid oxidation. Two
kinetically different isoforms, CPT-I α and CPT-I β, have been identified. Cardiac ventricular …

Abstract Camitine palmitoyltransferase-I (CPT-I) plays a crucial role in regulating cardiac
fatty acid oxidation which provides the primary source of energy for cardiac muscle …

Background/Purpose: The heart and kidney are both affected in sepsis-related multiple
organ failure. Both utilize fatty acid substrates during the neonatal period, and impairment of …

Rationale: Muscle carnitine palmitoyltransferase I is predominant in the heart, but the liver
isoform (liver carnitine palmitoyltransferase I [L-CPT1]) is elevated in hearts with low long …

The carnitine palmitoyltransferase-I (CPT-I) enzymes catalyze the regulated step in overall
mitochondrial fatty acid oxidation. The liver and muscle isoforms are expressed in liver and …

After birth, a dramatic increase in fatty acid oxidation occurs in the heart, which has been
attributed to an increase in l-carnitine levels and a switch from the liver (L) to muscle (M) …