Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐Jun N‐terminal kinase, and nuclear factor κB …
JA Mengshol, MP Vincenti, CI Coon… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To examine the mechanism of interleukin‐1 (IL‐1)–induced collagenase 3 (matrix
metalloproteinase 13 [MMP‐13]) gene expression in cultured chondrocytes for the purpose …
metalloproteinase 13 [MMP‐13]) gene expression in cultured chondrocytes for the purpose …
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK …
JA Mengshol, MP Vincenti… - Nucleic acids …, 2001 - academic.oup.com
Osteoarthritic chondrocytes secrete matrix metalloproteinase-13 (MMP-13) in response to
interleukin-1 (IL-1), causing digestion of type II collagen in cartilage. Using chondrocytic …
interleukin-1 (IL-1), causing digestion of type II collagen in cartilage. Using chondrocytic …
Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin‐1β‐stimulated synovial fibroblasts
MP Vincenti, CI Coon… - Arthritis & Rheumatism …, 1998 - Wiley Online Library
Objective To determine how interleukin‐1 (IL‐1), through activation of collagenase 1 (matrix
metalloproteinase 1 [MMP‐1]) transcription in synovial fibroblasts, contributes to cartilage …
metalloproteinase 1 [MMP‐1]) transcription in synovial fibroblasts, contributes to cartilage …
Role of mitogen-activated protein kinases and NFκB on IL-1β-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human …
Z Fan, H Yang, B Bau, S Söder, T Aigner - Rheumatology international, 2006 - Springer
Interleukin-1ß is a pro-inflammatory cytokine that causes anti-anabolic and catabolic effects
on articular chondrocytes via four major signaling pathways. In this study, we investigated …
on articular chondrocytes via four major signaling pathways. In this study, we investigated …
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix …
A Liacini, J Sylvester, WQ Li, M Zafarullah - Matrix Biology, 2002 - Elsevier
Interleukin-1 (IL-1), the main cytokine instigator of cartilage degeneration in arthritis, induces
matrix metalloproteinase-3 (MMP-3) and MMP-13 RNA and protein in chondrocytes. The …
matrix metalloproteinase-3 (MMP-3) and MMP-13 RNA and protein in chondrocytes. The …
Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal
SM Dai, ZZ Shan, K Nishioka, K Yudoh - Annals of the rheumatic …, 2005 - ard.bmj.com
Objective: To clarify the effect of interleukin (IL) 18 on cartilage degeneration by studying the
profile of IL18 receptor (IL18R) on chondrocytes and the direct effect of IL18 on production of …
profile of IL18 receptor (IL18R) on chondrocytes and the direct effect of IL18 on production of …
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis
HE Barksby, JM Milner, AM Patterson… - … : Official Journal of …, 2006 - Wiley Online Library
Objective We have previously reported the up‐regulation of matrix metalloproteinase 10
(MMP‐10) following treatment with the procatabolic stimulus of interleukin‐1 (IL‐1) and …
(MMP‐10) following treatment with the procatabolic stimulus of interleukin‐1 (IL‐1) and …
Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes
A Liacini, J Sylvester, WQ Li, W Huang… - Experimental cell …, 2003 - Elsevier
Tumor necrosis factor alpha (TNF-α), a major proinflammatory cytokine, induces arthritic joint
inflammation and resorption of cartilage by matrix metalloproteinase-13 (MMP-13). RNA for …
inflammation and resorption of cartilage by matrix metalloproteinase-13 (MMP-13). RNA for …
[HTML][HTML] Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific …
MP Vincenti, CE Brinckerhoff - Arthritis research & therapy, 2002 - Springer
Abstract Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial
collagenases that degrade type II collagen in cartilage; this is a committed step in the …
collagenases that degrade type II collagen in cartilage; this is a committed step in the …
Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis
BV Shlopov, ML Gumanovskaya… - Arthritis & Rheumatism …, 2000 - Wiley Online Library
Objective To correlate the increased collagenase production previously seen in
chondrocytes isolated from osteoarthritic (OA) lesions and the expression of cytokines and …
chondrocytes isolated from osteoarthritic (OA) lesions and the expression of cytokines and …
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