[HTML][HTML] Cathelicidins and defensins antimicrobial host defense peptides in the treatment of TB and HIV: Pharmacogenomic and nanomedicine approaches towards …

PN Dlozi, A Gladchuk, RD Crutchley, N Keuler… - Biomedicine & …, 2022 - Elsevier
Tuberculosis (TB) and human immunodeficiency virus (HIV) represent a significant burden
of disease on a global scale. Despite improvements in the global epidemic status, largely …

RECENT ADVANCES IN THE THERAPEUTIC POTENTIAL OF CATHELICIDINS

MES GUERRA, B Vieira, GV Destro, K Melo… - Frontiers in …, 2024 - frontiersin.org
The alarming increase in antimicrobial resistance in the last decades has prompted the
search for alternatives. Antimicrobial peptides (AMPs) represent a heterogeneous class of …

[HTML][HTML] Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential

NGJ Oliveira, MH Cardoso, N Velikova, M Giesbers… - Scientific Reports, 2020 - nature.com
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the
market are undermining our ability to treat human infections, leading to high mortality rates …

Antimicrobial peptides as novel anti-tuberculosis therapeutics

JP Silva, R Appelberg, FM Gama - Biotechnology advances, 2016 - Elsevier
Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis,
has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around …

Modulation of cathelicidin and defensins by histone deacetylase inhibitors: A potential treatment for multi-drug resistant infectious diseases

A Rodríguez-Carlos, YM Jacobo-Delgado… - Peptides, 2021 - Elsevier
Infectious diseases are an important growing public health problem, which perspective has
worsened due to the increasing number of drug-resistant strains in the last few years …

Multifunctional host defense peptides: antimicrobial peptides, the small yet big players in innate and adaptive immunity

C Auvynet, Y Rosenstein - The FEBS journal, 2009 - Wiley Online Library
The term 'antimicrobial peptides' refers to a large number of peptides first characterized on
the basis of their antibiotic and antifungal activities. In addition to their role as endogenous …

[图书][B] Antimicrobial peptides: discovery, design and novel therapeutic strategies

WGS Wang GuangShun - 2017 - cabidigitallibrary.org
Antimicrobial peptides (AMPs) have attracted extensive research attention worldwide.
Harnessing and creating AMPs synthetically has the potential to help overcome increasing …

[HTML][HTML] Antimicrobial peptides in innate immunity against mycobacteria

DM Shin, EK Jo - Immune Network, 2011 - synapse.koreamed.org
Antimicrobial peptides/proteins are ancient and naturallyoccurring antibiotics in innate
immune responses in a variety of organisms. Additionally, these peptides have been …

[HTML][HTML] Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

[HTML][HTML] Immuno-stimulatory peptides as a potential adjunct therapy against intra-macrophagic pathogens

T Silva, MS Gomes - Molecules, 2017 - mdpi.com
The treatment of infectious diseases is increasingly prone to failure due to the rapid spread
of antibiotic-resistant pathogens. Antimicrobial peptides (AMPs) are natural components of …