Diabetes mellitus can potentially be treated with islet transplantation, but additional sources
of β cells are necessary to overcome the short supply of donor pancreases. Although …

Macrophages are highly heterogeneous and plastic immune cells with peculiar
characteristics dependent on their origin and microenvironment. Following pathogen …

Efforts to restore β-cell number or mass in type 1 diabetes (T1D) must combine an
intervention to stimulate proliferation of remaining β-cells and an intervention to mitigate or …

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both
resident and recruited islet macrophages contribute to the proinflammatory milieu of the …

Macrophages are classically considered detrimental for pancreatic β-cell survival and
function, thereby contributing to β-cell failure in both type 1 (T1D) and 2 (T2D) diabetes …

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or
dysfunction of β-cells resulting in failure of metabolic control. Even though type 1 and 2 …

Diabetes is characterized by high blood glucose level due to either autoimmune destruction
of islet β-cells or insufficient insulin secretion or glucose non-responsive production of …

Diabetes, particularly type 1 diabetes, results from the lack of pancreatic β-cells. β-cell
replenishment can functionally reverse diabetes, but two critical challenges face the field: 1 …

Aims/hypothesis Mild islet inflammation has been suggested as a contributing factor to beta
cell failure in type 2 diabetes. Macrophage levels are elevated in the islets of humans and …

Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading
to insulin deficiency. Although infiltrating immune cells are traditionally considered to …