Physical exercise has been shown to exert antidepressant effects, but the mechanisms
underlying this effect are not completely elucidated. Therefore, we aimed at investigating the …

Exercise can improve cognitive function and the outcome of neurodegenerative diseases
like Alzheimer's disease. This effect has been linked to the increased expression of brain …

Exercise can improve cognitive function and the outcome of neurodegenerative diseases,
like Alzheimer's disease. This effect has been linked to the increased expression of brain …

Several lines of evidence have consistently indicated that physical exercise has
antidepressant effects by improving hippocampal function, although the signaling pathways …

Evidence has indicated that the practice of physical exercise has antidepressant effects that
might be associated with irisin release and BDNF signaling. In this study we investigated the …

The proportion of elderly populations is rapidly booming, and human lifespan has
considerably increased in the past century because of scientific and medical advances …

Irisin, the circulating peptide originating from fibronectin type III domain-containing protein 5
(FNDC5), is mainly expressed by muscle fibers under peroxisome proliferator-activated …

Featured Application Aerobic exercise has a significant impact upon cognitive function in
aging, and the FNDC5/irisin system exerts an interesting role as an important exercise …

The positive effects of physical exercise (EX) are well known to be mediated by cerebral
BDNF (brain-derived neurotrophic factor), a neurotrophin involved in learning and memory …

Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases
have high prevalence among the elderly. Many strategies have been established to alleviate …