Microtubules are dynamic polymers that occur in eukaryotic cells and play important roles in
cell division, motility, transport and signaling. They form during the process of polymerization …

This compound was found to cause mitotic arrest in L1210 murine leukemia cells, inhibit
tubulin polymerization, and competitively inhibit the binding of radiolabeled colchicine to …

Nature provides a large spectrum of agents that either inhibit the polymerization of tubulin or
prevent the disassembly of microtubules. Some of them are already used as anticancer …

This review provides an overview of the discovery, structures, and biological activities of
anticancer natural products that act by inhibiting or promoting the assembly of tubulin to …

The synthesis of twenty-six 4-arylcoumarin analogues of combretastatin A-4 (CA-4) led to
the identification of two new compounds (25 and 26) with strong cytotoxic activity. Both …

Tubulin, the major structural component of microtubules, is a target for the development of
anticancer agents. Two series of 1, 5-diaryl substituted 1, 2, 3, 4-tetrazoles were concisely …

A novel series of dihydronaphthalene and benzosuberene analogs bearing structural
similarity to the combretastatins in terms of 1, 2-diarylethene, trimethoxyphenyl, and biaryl …

Microtubules form crucial dynamic structural cellular components of the cell and are
composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide …

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity
study was carried out to characterise the interaction of these agents with tubulin. The …

The synthesis and antiproliferative activity of a new series of rigid analogues of
combretastatin A-4 are described which contain the 1, 4-diaryl-2-azetidinone (β-lactam) ring …