Acetylation of histone and nonhistone proteins is an important posttranslational modification
affecting many cellular processes. Here, we report that NuA4 acetylation of Sip2, a …

Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and
stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span …

AMP-activated protein kinase (AMPK) and its yeast homolog, Snf1, are critical regulators in
the maintenance of energy metabolic balance not only stimulating energy production but …

ABSTRACT AMP-activated protein kinase (AMPK) and the homologous yeast SNF1
complex are key regulators of energy metabolism that counteract nutrient deficiency and …

Cells undergoing developmental processes are characterized by persistent non-genetic
alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA …

Elevated proteasome activity extends lifespan in model organisms such as yeast, worms
and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as …

Histone acetyltransferases (HATs) are important enzymes that transfer acetyl groups onto
histones and thereby regulate both gene expression and chromosomal structures. Previous …

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in
multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) conduct many critical
functions through nonhistone substrates in metazoans, but only chromatin-associated …

Abstract Background Three kinases: Sch9, PKA and TOR, are suggested to be involved in
both the replicative and chronological ageing in yeast. They function in pathways whose …