The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

Extracting microanatomical information beyond the image resolution of MRI would provide
valuable tools for diagnostics and neuroscientific research. A number of mathematical …

Purpose Diffusion magnetic resonance imaging (MRI) microstructure imaging provides a
unique noninvasive probe into tissue microstructure. The technique relies on biophysically …

Advances in biophysical multi-compartment modeling for diffusion MRI (dMRI) have gained
popularity because of greater specificity than DTI in relating the dMRI signal to underlying …

Diffusion MRI is a non-invasive technique to study brain microstructure. Differences in the
microstructural properties of tissue, including size and anisotropy, can be represented in the …

Diffusion-sensitized magnetic resonance imaging probes the cellular structure of the human
brain, but the primary microstructural information gets lost in averaging over higher-level …

We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Diffusion MRI uses the random displacement of water molecules to sensitize the signal to
brain microstructure and to properties such as the density and shape of cells. Microstructure …

This article introduces a new and general framework for optimizing the experiment design
for diffusion MRI of samples with unknown orientation. An illustration then uses the …