Gene fusions are common driver events in leukaemias and solid tumours; here we present
FusionAnalyser, a tool dedicated to the identification of driver fusion rearrangements in …

Motivation: Comrad is a novel algorithmic framework for the integrated analysis of RNA-Seq
and whole genome shotgun sequencing (WGSS) data for the purposes of discovering …

We have developed FusionSeq to identify fusion transcripts from paired-end RNA-
sequencing. FusionSeq includes filters to remove spurious candidate fusions with artifacts …

Background We have evaluated an NGS-based method to detect recurrent gene fusions of
diagnostic and prognostic importance in hematological malignancies. Our goal was to …

Paired-end sequencing is emerging as a key technique for assessing genome
rearrangements and structural variation on a genome-wide scale. This technique is …

Several fusion genes are directly involved in the initiation and progression of cancers.
Numerous bioinformatics tools have been developed to detect fusion events, but they are …

Next-generation DNA sequencing (NGS) of the genomes of cancer cells is contributing to
new discoveries that illuminate the mechanisms of tumorigenesis. To this end, the …

The molecular analysis of recurring chromosome rearrangements, especially of
translocations and inversions, has provided us with valuable insight into the pathogenesis of …

Gene fusion represents a class of molecular aberrations in cancer and has been exploited
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …

Chromosomal rearrangements that result in oncogenic gene fusions are clinically important
drivers of many cancer types. Rapid and sensitive methods are therefore needed to detect a …