Since the original description of the structure of the antiprogestin, mifepristone, was
published, numerous related compounds have been synthesized which may function as …

Both progesterone receptor modulators (PRMs) as well as pure progesterone antagonists
(PAs) have numerous proven and potential therapeutic applications in female health care …

Since the discovery of the antiprogestin mifepristone, hundreds of similar compounds have
been synthesized, which can be grouped in a large family of progesterone receptor ligands …

Since the discovery of the antiprogestin RU 486 (mifepristone), other compounds have been
synthesised that function as pure progesterone antagonists or progesterone receptor …

Since the discovery of the progesterone receptor antagonist mifepristone, numerous
additional compounds, which display a spectrum of biological actions ranging from full …

Progesterone antagonists (PAs) and progesterone receptor modulators (PRMs) have
contraceptive potential by suppressing follicular development, delaying the surge of …

OBJECTIVE: To discuss the mechanism of action of selective progesterone receptor
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …

Many processes in female reproductive physiology depend on progesterone. This hormone
facilitates the action of estradiol in inducing the luteinizing hormone (LH) surge in the …

Background: A number of synthetic steroids are capable of modulating progesterone
receptors with a spectrum of activities ranging from pure antagonism to a mixture of agonism …

Antiprogestins are characterized by substitutions at the 118 and 17a positions of the steroid
ring system and bind strongly to both progesterone and glucocorticoid receptors. Although …