[HTML][HTML] Waves, patterns, bifurcations: A tutorial review on the vertebrate segmentation clock

P François, V Mochulska - Physics Reports, 2024 - Elsevier
Proper vertebrae formation relies on a tissue-wide oscillator called the segmentation clock.
Individual cellular oscillators in the presomitic mesoderm are modulated by intercellular …

Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock

AC Oates, LG Morelli, S Ares - Development, 2012 - journals.biologists.com
The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

Delayed coupling theory of vertebrate segmentation

LG Morelli, S Ares, L Herrgen, C Schröter, F Jülicher… - HFSP …, 2009 - Taylor & Francis
Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into
morphological somites is controlled by an oscillating multicellular genetic network termed …

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

LA Rohde, A Bercowsky-Rama, G Valentin… - bioRxiv, 2021 - biorxiv.org
Rhythmic and sequential segmentation of the growing vertebrate body relies on the
segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue …

[HTML][HTML] From signalling oscillations to somite formation

WHM Meijer, KF Sonnen - Current Opinion in Systems Biology, 2024 - Elsevier
Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic
network of signalling pathways. Signalling gradients determine the spacing of the forming …

In vitro systems: A new window to the segmentation clock

M Diaz‐Cuadros, O Pourquie - Development, Growth & …, 2021 - Wiley Online Library
Segmental organization of the vertebrate body plan is established by the segmentation
clock, a molecular oscillator that controls the periodicity of somite formation. Given the …

[HTML][HTML] Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks

AC Oates - Current Opinion in Genetics & Development, 2020 - Elsevier
The rhythmic and sequential segmentation of the vertebrate body axis into somites during
embryogenesis is governed by a multicellular, oscillatory patterning system called the …

A mechanical perspective on vertebral segmentation

L Truskinovsky, G Vitale, TH Smit - International Journal of Engineering …, 2014 - Elsevier
Segmentation is a characteristic feature of the vertebrate body plan. The prevailing
paradigm explaining its origin is the 'clock and wave-front'model, which assumes that the …

Cell cycle regulation of oscillations yields coupling of growth and form in a computational model of the presomitic mesoderm

PJ Murray, FA Carrieri, JK Dale - Journal of Theoretical Biology, 2019 - Elsevier
A striking example of coupling between growth and form occurs during the segmentation of
the vertebrate embryo. During segmentation, pairs of segments, one on either side of the …

[HTML][HTML] Segmentation clock dynamics is strongly synchronized in the forming somite

R Bhavna - Developmental biology, 2020 - Elsevier
During vertebrate somitogenesis an inherent segmentation clock coordinates the
spatiotemporal signaling to generate segmented structures that pattern the body axis. Using …