Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptins, a family of neuropeptides encoded by the Kiss1 gene that are mainly expressed
in discrete neuronal populations of the hypothalamus, have recently emerged as essential …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptins are a group of peptides that stimulate GnRH release and are required for
puberty and maintenance of normal reproductive function. This review focuses on our …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

Kisspeptins, the peptide products of the Kiss1 gene, were initially identified in mammals as
ligands of the G protein-coupled receptor 54 (GPR54; also termed Kiss1R) with ability to …

Gonadotrophin‐releasing hormone (GnRH) is the primary hypothalamic factor responsible
for the control of gonadotrophin secretion in vertebrates. However, within the last decade …

Neurons that produce gonadotropin-releasing hormone (GnRH) reside in the basal
forebrain and drive reproductive function in mammals. Understanding the circuitry that …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Kisspeptin binding to its G-protein-coupled receptor KISS1R (also known as GPR54), which
is expressed by gonadotropin-releasing hormone (GnRH) neurons, stimulates GnRH …