Increased prefrontal GABA concentrations in adults with autism spectrum disorders

S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …

Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and …

A Carvalho Pereira, IR Violante, S Mouga… - Journal of Autism and …, 2018 - Springer
The nature of neurochemical changes in autism spectrum disorder (ASD) remains
controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high …

[HTML][HTML] Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance …

L Tebartz van Elst, S Maier, T Fangmeier… - Molecular …, 2014 - nature.com
Over the last few years, awareness of autism spectrum disorder (ASD) in adults has
increased. The precise etiology of ASD is still unresolved. Animal research, genetic and …

Concentrations of cortical GABA and glutamate in young adults with autism spectrum disorder

T Kolodny, MP Schallmo, J Gerdts… - Autism …, 2020 - Wiley Online Library
The balance of excitation and inhibition in neural circuits is hypothesized to be increased in
autism spectrum disorder, possibly mediated by altered signaling of the inhibitory …

[HTML][HTML] Brain MR spectroscopy in autism spectrum disorder—the GABA excitatory/inhibitory imbalance theory revisited

MK Brix, L Ersland, K Hugdahl, R Grüner… - Frontiers in human …, 2015 - frontiersin.org
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate
cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 …

Relationship among glutamine, γ-aminobutyric acid, and social cognition in autism spectrum disorders

DM Cochran, EM Sikoglu, SM Hodge… - Journal of child and …, 2015 - liebertpub.com
Objective: An imbalance of excitatory and inhibitory neurotransmission in autism spectrum
disorder (ASD) has been proposed. We compared glutamate (Glu), glutamine (Gln), and γ …

Decreased left perisylvian GABA concentration in children with autism and unaffected siblings

DC Rojas, D Singel, S Steinmetz, S Hepburn… - Neuroimage, 2014 - Elsevier
Imbalanced levels of excitation and inhibition (E/I) have been proposed to account for
various behavioral and electrophysiological phenotypes in autism. Although proton …

Altered neurotransmitter metabolism in adolescents with high-functioning autism

GS Drenthen, EM Barendse, AP Aldenkamp… - Psychiatry Research …, 2016 - Elsevier
Previous studies have suggested that alterations in excitatory/inhibitory neurotransmitters
might play a crucial role in autism spectrum disorder (ASD). Proton magnetic resonance …

[HTML][HTML] Thalamic and prefrontal GABA concentrations but not GABAA receptor densities are altered in high-functioning adults with autism spectrum disorder

LK Fung, RE Flores, M Gu, KL Sun, D James… - Molecular …, 2021 - nature.com
The gamma aminobutyric acid (GABA) neurotransmission system has been implicated in
autism spectrum disorder (ASD). Molecular neuroimaging studies incorporating …

[HTML][HTML] Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

G Park, SJ Jeon, IO Ko, JH Park, KC Lee, MS Kim… - Molecular brain, 2022 - Springer
To diagnose autism spectrum disorder (ASD), researchers have sought biomarkers whose
alterations correlate with the susceptibility to ASD. However, biomarkers closely related to …