Background Multiple sclerosis (MS) leads to demyelination and neurodegeneration with
autoimmune responses in central nervous system. Patients begin with a relapsing–remitting …

Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS),
commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes …

Background Emerging evidence of antibody-independent functions, as well as the clinical
efficacy of anti-CD20 depleting therapies, helped to reassess the contribution of B cells …

MS is thought to be mediated by CD4+ T-helper cells. To investigate the importance of CD8+
cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma …

Background and Objectives Multiple sclerosis (MS) is a chronic inflammatory and
demyelinating disease of the CNS. Studies of immune dysfunction in MS have mostly …

Background Increasing evidence indicates the importance of CD8+ T cells in autoimmune
attack against CNS myelin and axon in multiple sclerosis (MS). Previous research has also …

Objective: We investigated T cell responses to myelin proteins in the blood of healthy
controls and 2 groups of patients with relapsing-remitting multiple sclerosis (RRMS) who …

Multiple sclerosis (MS) is a common and devastating chronic inflammatory disease of the
CNS. CD4+ T cells are assumed to be the first to cross the blood–central nervous system …

Neutrophils and monocytes encompassing the classical, intermediate, and nonclassical
population constitute the majority of circulating myeloid cells in humans and represent the …

Objectives Using flow cytometry, we characterized myeloid, B, and T cells in patients
recently diagnosed with relapsing–remitting multiple sclerosis (RRMS) naive to disease …