Background: Non-syndromic combined pituitary hormone deficiency (CPHD) occurs due to
defects in transcription factors that govern early pituitary development and the specification …

Objective Homozygous mutations in the gene encoding the pituitary transcription factor
PROP1 are associated with combined pituitary hormone deficiency (CPHD) in both mice …

Background and Objectives: Combined pituitary hormone deficiency (CPHD) is a rare
heterogeneous disease. It is characterized by the deficiency of growth hormone (GH) and …

Objective Mutations of the PROP1 gene lead to combined pituitary hormone deficiency
(CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less …

Objective: Mutations of the genes encoding transcription factors which play important roles
in pituitary morphogenesis, differentiation and maturation may lead to combined pituitary …

Objective Mutations within the pituitary‐specific paired‐like homeobox gene PROP1 have
been described in 50–100% of patients with familial combined pituitary hormone deficiency …

Objective PROP1 mutations are the most common cause of genetic combined pituitary
hormone deficiency (CPHD). The aim of this study was to investigate the PROP1 gene in two …

Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in
8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an …

The most commonly identified genetic cause of combined pituitary hormone deficiency
(CPHD) is PROP1 gene mutations. The aim of the study was to compare selected clinical …

Combined pituitary hormone deficiency (CPHD), including growth hormone (GH), prolactin
(Prl) and thyroid-stimulating hormone (TSH) in children is now considered a heterogeneous …