Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …

Significance: Here, we review certain recent advances in oxidative stress and tumor
metabolism, which are related to understanding the contributions of the microenvironment in …

We have recently proposed a new model for understanding how tumors evolve. To achieve
successful" Tumor-Stroma Co-Evolution", cancer cells induce oxidative stress in adjacent …

Glutamine metabolism is crucial for cancer cell growth via the generation of intermediate
molecules in the tricarboxylic acid (TCA) cycle, antioxidants and ammonia. The goal of the …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Previously, we proposed a new paradigm to explain the compartment-specific role of
autophagy in tumor metabolism. In this model, autophagy and mitochondrial dysfunction in …

We have recently proposed a new two-compartment model for understanding the Warburg
effect in tumor metabolism. In this model, glycolytic stromal cells produce mitochondrial fuels …

Autophagy is a highly regulated‐cell pathway for degrading long‐lived proteins as well as
for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis …

We have previously demonstrated that enhanced aerobic glycolysis and/or autophagy in the
tumor stroma supports epithelial cancer cell growth and aggressive behavior, via the …

Previously, we proposed a new model for understanding the Warburg effect in
tumorigenesis and metastasis. In this model, the stromal fibroblasts would undergo aerobic …