NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions
HH Tai, H Cho, M Tong, Y Ding - Current pharmaceutical …, 2006 - ingentaconnect.com
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation
of 15 (S)-hydroxyl group of prostaglandins and lipoxins resulting in the formation of 15-keto …
of 15 (S)-hydroxyl group of prostaglandins and lipoxins resulting in the formation of 15-keto …
Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2
H Cho, L Huang, A Hamza, D Gao, CG Zhan… - Bioorganic & medicinal …, 2006 - Elsevier
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the
short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic …
short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic …
15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
HH Tai, M Tong, Y Ding - Prostaglandins & other lipid mediators, 2007 - Elsevier
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD+-linked oxidation of
15 (S)-hydroxyl group of prostaglandins and lipoxins and is the key enzyme responsible for …
15 (S)-hydroxyl group of prostaglandins and lipoxins and is the key enzyme responsible for …
High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships
Background 15-hydroxyprostaglandin dehydrogenase (15-PGDH, EC 1.1. 1.141) is the key
enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or …
enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or …
NAD + -linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
It has been reported that two inducible prostaglandin synthetic enzymes, cylooxygenase-2
(COX-2) and microsomal PGE synthase, are over-expressed in non-small cell lung cancer …
(COX-2) and microsomal PGE synthase, are over-expressed in non-small cell lung cancer …
Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents
H Cho, HH Tai - Prostaglandins, leukotrienes and essential fatty acids, 2002 - Elsevier
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes NAD+-dependent oxidation
of 15 (S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved …
of 15 (S)-hydroxyl group of prostaglandins and has been considered a key enzyme involved …
Threonine 188 is critical for interaction with NAD+ in human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme
in the inactivation pathway of prostaglandins. It is a member of the short-chain …
in the inactivation pathway of prostaglandins. It is a member of the short-chain …
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy
HK Na, JM Park, HG Lee, HN Lee, SJ Myung… - Biochemical …, 2011 - Elsevier
Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in arachidonic acid cascade, plays a key
role in the biosynthesis of prostaglandin E2 (PGE2) upon inflammatory insults …
role in the biosynthesis of prostaglandin E2 (PGE2) upon inflammatory insults …
[PDF][PDF] 15-Hydroxyprostaglandin dehydrogenase
NAD+-dependent 15hydroxyprostaglandin dehydrogenase(15-PGDH, type I) is considered
to be the key catabolic enzyme which controls the biological activity of the prostaglandins …
to be the key catabolic enzyme which controls the biological activity of the prostaglandins …
Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins
CC Sun, ZQ Zhou, D Yang, ZL Chen, YY Zhou… - International …, 2021 - Elsevier
hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously
expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; …
expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; …