Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …

With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Cellular senescence was first described as a physiological tumor cell suppressor
mechanism that leads to cell growth arrest with production of the senescence-associated …

With increasing age, the ability of the adaptive immune system to respond to vaccines and to
protect from infection declines. In parallel, the production of inflammatory mediators …