Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn

ME Mitchell, LC Cook, S Shiers… - Journal of …, 2023 - Wiley Online Library
Abstract Fragile X Mental Retardation Protein (FMRP) regulates activity‐dependent RNA
localization and local translation to modulate synaptic plasticity throughout the central …

Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR

TJ Price, MH Rashid, M Millecamps… - Journal of …, 2007 - Soc Neuroscience
Fragile X mental retardation is caused by silencing of the gene (FMR1) that encodes the
RNA-binding protein (FMRP) that influences translation in neurons. A prominent feature of …

Fragile X mental retardation protein (FMRP) and the spinal sensory system

TJ Price, OK Melemedjian - Modeling Fragile X Syndrome, 2012 - Springer
The purpose of this chapter is to discuss the role of the fragile X mental retardation protein
(FMRP) in the spinal sensory system and the potential for use of the mouse model of fragile …

Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions

MR Akins, HF LeBlanc, EE Stackpole… - Journal of …, 2012 - Wiley Online Library
Loss of Fragile X mental retardation protein (FMRP) leads to Fragile X syndrome (FXS), the
most common form of inherited intellectual disability and autism. Although the functions of …

[PDF][PDF] Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice

EG Harlow, SM Till, TA Russell, LS Wijetunge, P Kind… - Neuron, 2010 - cell.com
Alterations in sensory processing constitute prominent symptoms of fragile X syndrome;
however, little is known about how disrupted synaptic and circuit development in sensory …

Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

LN Antar, R Afroz, JB Dictenberg… - Journal of …, 2004 - Soc Neuroscience
Fragile X syndrome is caused by the absence of the mRNA-binding protein Fragile X mental
retardation protein (FMRP), which may play a role in activity-regulated localization and …

Fragile X mental retardation protein‐regulated proinflammatory cytokine expression in the spinal cord contributes to the pathogenesis of inflammatory pain induced by …

Y Yang, J Zhao, Y Li, X Li, X Chen… - Journal of …, 2021 - Wiley Online Library
Studies have verified that Fragile X mental retardation protein (FMRP), an RNA‐binding
protein, plays a potential role in the pathogenesis of formalin‐and (RS)‐3, 5 …

[PDF][PDF] Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function

GJ Bassell, ST Warren - Neuron, 2008 - cell.com
Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion …

Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation

BE Pfeiffer, KM Huber - Journal of neuroscience, 2007 - Soc Neuroscience
Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of …

Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons

JD Graef, H Wu, C Ng, C Sun, V Villegas… - European Journal of …, 2020 - Wiley Online Library
Fragile X syndrome (FXS) is the most common genetic form of intellectual disability caused
by a CGG repeat expansion in the 5′‐UTR of the Fragile X mental retardation gene FMR1 …