Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake
VS Subramanian, T Teafatiller, J Vidal, GS Gunaratne… - 2021 - escholarship.org
Ascorbic acid (AA) uptake in neurons occurs via a Na+-dependent carrier-mediated process
mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little …
mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little …
Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake
VS Subramanian, T Teafatiller, J Vidal… - International journal of …, 2021 - Elsevier
Ascorbic acid (AA) uptake in neurons occurs via a Na+-dependent carrier-mediated process
mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little …
mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little …
Vitamin C transport in neurons and epithelia is regulated by secretory carrier-associated membrane protein-2 (SCAMP2)
The human sodium-dependent vitamin C transporter-1 (hSVCT1) is localized at the apical
membrane domain of polarized intestinal and renal epithelial cells to mediate ascorbic acid …
membrane domain of polarized intestinal and renal epithelial cells to mediate ascorbic acid …
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells
MDLA García, K Salazar, C Millán, F Rodríguez… - Glia, 2005 - Wiley Online Library
Kinetic analysis of vitamin C uptake demonstrated that different specialized cells take up
ascorbic acid through sodium–vitamin C cotransporters. Recently, two different isoforms of …
ascorbic acid through sodium–vitamin C cotransporters. Recently, two different isoforms of …
Valproic acid regulates sodium‐dependent vitamin C transporter‐2 (SVCT‐2) functional expression in neuronal cells
T Teafatiller, VS Subramanian - The FASEB Journal, 2022 - Wiley Online Library
Neuronal uptake of ascorbic acid (AA) in humans occurs via the human sodium‐dependent
vitamin C transporter‐2 (hSVCT2; the product of the SLC23A2gene). Studies have shown …
vitamin C transporter‐2 (hSVCT2; the product of the SLC23A2gene). Studies have shown …
SVCT2 overexpression and ascorbic acid uptake increase cortical neuron differentiation, which is dependent on vitamin c recycling between neurons and astrocytes
K Salazar, F Espinoza, G Cerda-Gallardo, L Ferrada… - Antioxidants, 2021 - mdpi.com
During brain development, sodium–vitamin C transporter (SVCT2) has been detected
primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex …
primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex …
SVCT2 transporter expression is post‐natally induced in cortical neurons and its function is regulated by its short isoform
K Salazar, G Cerda, F Martínez… - Journal of …, 2014 - Wiley Online Library
Different studies have demonstrated the importance of micronutrients, such as vitamins, for
normal adult brain function and development. Vitamin C is not synthesized in the brain, but …
normal adult brain function and development. Vitamin C is not synthesized in the brain, but …
SVCT1 (Slc23a1) knockout mice: Slc23a1 as the vitamin C kidney reabsorptive transporter
Vitamin C pharmacokinetics in humans indicate that the renal threshold of excretion is
responsible for tightly controlled concentrations of the vitamin in plasma and accumulated in …
responsible for tightly controlled concentrations of the vitamin in plasma and accumulated in …
Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells
VS Subramanian, JS Marchant… - American Journal of …, 2010 - journals.physiology.org
The human sodium-dependent vitamin C transporter-2 (hSVCT2) plays an important role in
cellular accumulation of ascorbic acid in liver cells. However, little is known about the …
cellular accumulation of ascorbic acid in liver cells. However, little is known about the …
Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion
ME Meredith, FE Harrison, JM May - Biochemical and biophysical research …, 2011 - Elsevier
The sodium-dependent vitamin C transporter-2 (SVCT2) is the only ascorbic acid (ASC)
transporter significantly expressed in brain. It is required for life and is critical during brain …
transporter significantly expressed in brain. It is required for life and is critical during brain …