Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and
recent studies in the hippocampus found that LTP was impaired in aged animals. Previous …

In the brain, the TrkA receptor for Nerve Growth Factor (NGF) is expressed primarily in the
cholinergic system. TrkA/NGF support neuronal health and function, and deficiencies in this …

Age-dependent alterations in the induction of long-term potentiation (LTP) are well
documented, providing a likely neural basis for memory decline associated with aging …

During aging, memory retention and persistence of long-term potentiation (LTP) are
impaired, suggesting an aging-related deterioration in mechanisms regulating information …

Several signaling mechanisms that are crucial for the induction of long-term potentiation
(LTP) by theta frequency (5Hz) trains of synaptic stimulation are altered in aged animals. To …

Altered hippocampal synaptic plasticity may underlie age-related memory impairment. In
acute hippocampal slices from aged (22–24 mo) and young adult (1–12 mo) male Brown …

Loss of neuropeptide Y (NPY)-expressing interneurons in the hippocampus and decaying
cholinergic neuromodulation are thought to contribute to impaired cognitive function during …

Cognitive decline observed in aging mammals is associated with decreased long-term
synaptic plasticity, especially long-term potentiation (LTP). Recent work has uncovered a …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

Long-term potentiation (LTP) is a form of synaptic plasticity thought to underlie memory; thus
knowing its developmental profile is fundamental to understanding function. Like memory …