Proteomic approaches to study ubiquitinomics
As originally described some 40 years ago, protein ubiquitination was thought to serve
primarily as a static mark for protein degradation. In the ensuing years, it has become clear …
primarily as a static mark for protein degradation. In the ensuing years, it has become clear …
Dissecting the ubiquitin pathway by mass spectrometry
Protein modification by ubiquitin is a central regulatory mechanism in eukaryotic cells.
Recent proteomics developments in mass spectrometry enable systematic analysis of …
Recent proteomics developments in mass spectrometry enable systematic analysis of …
Quantitative proteomics to decipher ubiquitin signaling
Ubiquitin signaling plays an essential role in controlling cellular processes in eukaryotes,
and the impairment of ubiquitin regulation contributes to the pathogenesis of a wide range of …
and the impairment of ubiquitin regulation contributes to the pathogenesis of a wide range of …
Decoding the ubiquitin landscape by cutting-edge ubiquitinomic approaches
B PT, I Sahu - Biochemical Society Transactions, 2024 - portlandpress.com
Functional consequences of protein ubiquitination have gone far beyond the degradation
regulation as was initially imagined during its discovery 40 years back. The state-of-the-art …
regulation as was initially imagined during its discovery 40 years back. The state-of-the-art …
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
DS Kirkpatrick, C Denison, SP Gygi - Nature cell biology, 2005 - nature.com
Mass-spectrometry-based proteomics has become an essential tool for the qualitative and
quantitative analysis of cellular systems. The biochemical complexity and functional diversity …
quantitative analysis of cellular systems. The biochemical complexity and functional diversity …
Ubiquitinomics: History, methods, and applications in basic research and drug discovery
The ubiquitin‐proteasome system (UPS) was discovered about 40 years ago and is known
to regulate a multitude of cellular processes including protein homeostasis. Ubiquitylated …
to regulate a multitude of cellular processes including protein homeostasis. Ubiquitylated …
Evaluation of proteomic strategies for analyzing ubiquitinated proteins
JM Peng - BMB reports, 2008 - koreascience.kr
Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It
covalently modifies a wide variety of targeted proteins in the forms of monomer and …
covalently modifies a wide variety of targeted proteins in the forms of monomer and …
[HTML][HTML] Ubiquitin—omics reveals novel networks and associations with human disease
BM Kessler - Current opinion in chemical biology, 2013 - Elsevier
Human neurodegenerative and infectious diseases and tumorigenesis are associated with
alterations in ubiquitin pathways. Over 10% of the genome encode for genes that either bind …
alterations in ubiquitin pathways. Over 10% of the genome encode for genes that either bind …
The ubiquitin proteoform problem
KK Deol, ER Strieter - Current opinion in chemical biology, 2021 - Elsevier
The diversity of ubiquitin modifications is immense. A protein can be monoubiquitylated,
multi-monoubiquitylated, and polyubiquitylated with chains varying in size and shape …
multi-monoubiquitylated, and polyubiquitylated with chains varying in size and shape …
Proteomic techniques to probe the ubiquitin landscape
Protein ubiquitination is a powerful modulator of cellular functions. Classically linked to the
degradation of proteins, it also plays a role in intracellular localization, DNA damage …
degradation of proteins, it also plays a role in intracellular localization, DNA damage …