We demonstrate a combined experimental and computational approach for the quantitative
characterization of lateral interactions between membrane-associated proteins. In particular …

Cadherin transmembrane proteins are responsible for intercellular adhesion in all biological
tissues and modulate tissue morphogenesis, cell motility, force transduction, and …

Cadherins constitute a family of cell-surface proteins that mediate intercellular adhesion
through the association of protomers presented from juxtaposed cells. Differential cadherin …

Cadherins mediate cell-cell adhesion through homophilic interactions. High-resolution
structures have greatly enhanced our understanding of this phenomenon over the past few …

While both cis and trans (adhesive)-interactions cooperate in the assembly of intercellular
adhesions, computational simulations have predicted that two-dimensional confinement …

The structures of many cell surface adhesion proteins comprise multiple tandem repeats of
structurally similar domains. In many cases, the functional significance of this architecture is …

Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are
different enough to mediate highly specific cell–cell recognition phenomena. It has …

The cadherin family of Ca2+-dependent cell adhesion proteins are critical for the
morphogenesis and functional organization of tissues in multicellular organisms, but the …

Numerous attempts to elucidate the strength of cadherin dimerization that mediates
intercellular adhesion have produced controversial and inconclusive results. To clarify this …

The extracellular homophilic-binding domain of the cadherins consists of 5 cadherin repeats
(EC1–EC5). Studies on cadherin specificity have implicated the NH2-terminal EC1 domain …