Background People age at remarkably different rates, but how to estimate trajectories of
senescence is controversial. Methods In a secondary analysis of a representative cohort of …

Background age-specific mortality reduction has been accompanied by a decrease in the
prevalence of some diseases and an increase in others. Whether populations are becoming …

Background. While on average health declines with age, it also becomes more variable with
age. As a consequence of this marked variability, it becomes more important as people age …

Background. Many definitions of frailty exist, but few have been directly compared. We
compared the relationship between a definition of frailty based on a specific phenotype with …

Background: There is no single generally accepted clinical definition of frailty. Previously
developed tools to assess frailty that have been shown to be predictive of death or need for …

OBJECTIVES: To determine whether adding cognitive impairment to frailty improves its
predictive validity for adverse health outcomes. DESIGN: Four‐year longitudinal study …

Background The prevalence of frailty increases with age in older adults, but frailty is largely
unreported for younger adults, where its associated risk is less clear. Furthermore, less is …

Background Although research productivity in the field of frailty has risen exponentially in
recent years, there remains a lack of consensus regarding the measurement of this …

Background. The concept of a frailty index, developed in Canadian elderly populations as
an indicator of biological age as opposed to chronological age, was tested in an elderly …

Frailty is measured to understand its nature and biology, to aid diagnosis and care planning,
to measure outcomes and to stratify risk. Such goals oblige two types of frailty measures—for …