Viruses can be engineered to efficiently deliver exogenous genes, but their natural gene
delivery properties often fail to meet human therapeutic needs. Therefore, engineering viral …

The success of gene therapy relies heavily on the performance of vectors that can effectively
deliver transgenes to desired cell populations. As viruses have evolved to deliver genetic …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

In comparison to classical medicines, gene therapy has the potential to mediate the highest
possible level of therapeutic specificity. Every normal or diseased cell can switch on or off a …

Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

▪ Abstract Significant progress has been made in the area of nonviral gene delivery to date.
Yet, synthetic vectors remain less efficient by orders of magnitude than their viral …

In a range of human trials, viral vectors have emerged as safe and effective delivery vehicles
for clinical gene therapy, particularly for monogenic recessive disorders, but there has also …

Integrating viral gene delivery with engineered biomaterials is a promising strategy to
overcome a number of challenges associated with virus-mediated gene delivery, including …

Gene therapy includes the application of various viral vectors, which represent most types
and families of viruses, suitable for infection of mammalian host cells. Both hereditary …

Gene therapy that can introduce, counteract, or replace genes possesses great potential to
address diseases at their genetic roots. A wide range of technologies, such as RNA …