Compared to terrestrial environments, the oceans harbor a variety of environments, creating
higher biodiversity, which gives marine natural products a high occurrence of significant …

Drug discovery is based on bioactivity screening of natural sources, traditionally represented
by bacteria fungi and plants. Bioactive natural products and their secondary metabolites …

Background Antibiotic resistance in bacteria spreads quickly, overtaking the pace at which
new compounds are discovered and this emphasizes the immediate need to discover new …

Marine microorganisms are rich source for natural products which play important roles in
pharmaceutical industry. Over the past decade, genome‐based studies of marine …

Background Marine prokaryotes are a rich source of novel bioactive secondary metabolites
for drug discovery. Recent genome mining studies have revealed their great potential to bio …

New drugs from silent gene clusters: Analysis of genome sequence data has identified
numerous “cryptic” gene clusters encoding novel natural product biosynthetic assembly …

Natural products have been an abundant source of leader compounds for new drugs, but
traditional isolation and analysis technologies to obtain novel natural products cannot satisfy …

The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

Genomics-based methods are now commonplace in natural products research. A phylogeny-
guided mining approach provides a means to quickly screen a large number of microbial …

Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …