Fibronectin (FN) is a major component of the tumor microenvironment, but its role in
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …

Oudin and colleagues report a novel and specific function of MENA in mediating directional
migration of breast cancer cells toward a fibronectin gradient of increasing concentration …

The most well studied mode of cell motility for metastasizing tumor cells is chemotaxis, the
directional movement of cells attracted to a source of soluble cues. In contrast, haptotaxis …

Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define
key developmental, physiological and pathological processes. Here, we report a new type of …

Most cancer deaths are due to metastasis, and almost all cancers have their preferential
metastatic organs, known as “organotropism metastasis”. Epithelial-mesenchymal plasticity …

Directed cell migration arises from cells following a microenvironmental gradient (eg of a
chemokine) or polarizing feature (eg a linear structure). However cells not only follow, but in …

Forced overexpression and/or downregulation of proteins regulating epithelial-to-
mesenchymal transition (EMT) has been reported to alter metastasis by changing migration …

Both epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET)
are linked to metastasis via their ability to increase invasiveness and enhance tumor …

Background: Metastasis, accounting for up to 90% of cancer-related deaths, remains one of
the least understood aspects of cancer progression. Recent research has shifted focus from …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …