Cellular metabolism plays a major role in the regulation of inflammation. The inflammatory
macrophages undergo a wide‐range of metabolic rewriting due to the production of …

Pathological conditions associated with dysfunctional wound healing are characterized by
impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and …

Functional remodeling and prolonged anti-inflammatory responses are both vital for
repairing damage in the cardiovascular system. Although these aspects have each been …

Itaconate is an immunomodulatory metabolite produced by immune cells under microbial
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …

Myocardial infarction (MI) is the serious condition causing lots of death over the world.
Myocytes apoptosis, inflammation, and fibrosis are three important factors implicated in …

Metabolic products can lead to crucial biological function alterations. Itaconate is probably
the best example of how a metabolic process can be diverted to generate an …

Inflammatory modulations focusing on macrophage phenotype are promising candidates to
promote better cardiac healing post myocardial ischemia‐reperfusion (MI/R) injury …

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after
infarction and thrombolytic therapy, and it is closely related to the free radical explosion and …

Induction of cardiac muscle regeneration following myocardial infarction (MI) represents a
major challenge in cardiovascular therapy, as the current clinical approaches are limited in …

Macrophages play a central role in innate immunity as the first line of defense against
pathogen infection. Upon exposure to inflammatory stimuli, macrophages rapidly respond …