Pharmacokinetics, tissue distribution, and druggability prediction of the natural anticancer active compound cytisine n-isoflavones combined with computer simulation
F Chen, X Yin, Y Wang, Y Lv, S Sheng… - Biological and …, 2020 - jstage.jst.go.jp
Abstract Cytisine N-methylene-(5, 7-dihydroxy-4′-methoxy)-isoflavone (CNF2) is a new
compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary …
compound isolated from the Chinese herbal medicine Sophora alopecuroides. Preliminary …
Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors
Y Wang, X Yin, L Chen, Z Yin, Z Zuo - Bioorganic Chemistry, 2022 - Elsevier
Aberrant signaling of EGFR (ErbB) family members, in particular epidermal growth factor
receptor (EGFR) and human epidermal growth factor 2 (HER2), is associated with the …
receptor (EGFR) and human epidermal growth factor 2 (HER2), is associated with the …
[HTML][HTML] Study on the molecular mechanism of anti-liver cancer effect of Evodiae fructus by network pharmacology and QSAR model
PY Chen, LT Han - Frontiers in Chemistry, 2023 - frontiersin.org
Introduction: Evodiae Fructus (EF) is the dried, near ripe fruit of Euodia rutaecarpa (Juss.)
Benth in Rutaceae. Numerous studies have demonstrated its anti-liver cancer properties …
Benth in Rutaceae. Numerous studies have demonstrated its anti-liver cancer properties …
In silico identification of novel flavonoids targeting epidermal growth factor receptor
Background: Epidermal growth factor receptor (EGFR, ErBb) belongs to family of receptor
tyrosine kinase (RTKs) that plays an important role in multiple cell signaling pathways, which …
tyrosine kinase (RTKs) that plays an important role in multiple cell signaling pathways, which …
Structure–Activity Relationship Prediction‐Based Synthesis and Cytotoxicity Evaluation against the HEp‐2 Laryngeal Carcinoma Cell of Isoflavone–Cytisine Mannich …
G Mrug, D Hodyna, L Metelytsia… - Chemistry & …, 2023 - Wiley Online Library
QSAR analysis of previously synthesized and nature‐inspired virtual isoflavone‐cytisine
hybrids against the HEp‐2 laryngeal carcinoma cell lines was performed using the OCHEM …
hybrids against the HEp‐2 laryngeal carcinoma cell lines was performed using the OCHEM …
Comparative in vitro and in silico characterization of anticancer compounds piceatannol, biochanin-A and resveratrol on breast cancer cells
P Mathi, N Musunuru, M Botlagunta - Pharmacognosy Magazine, 2019 - phcog.com
Background: Biochanin-A and Piceatannol are phytochemical constituents extracted from
Sophora interrupta. Although both the compounds were isolated from a single plant, these …
Sophora interrupta. Although both the compounds were isolated from a single plant, these …
Anti-proliferative tirucallane triterpenoids from gum resin of Boswellia sacra
B Zhang, D Liu, S Cao, T Yao, G Liu, L Chen, F Qiu - Bioorganic Chemistry, 2022 - Elsevier
Abstract Eight new tirucallane triterpenoids (1–2, 5–10) along with two known compounds (3–
4) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by …
4) were isolated from the gum resin of Boswellia sacra. Their structures were elucidated by …
In vitro and in silico characterization of angiogenic inhibitors from Sophora interrupta
P Mathi, GK Veeramachaneni, KK Raj… - Journal of molecular …, 2016 - Springer
Abstract Sophora interrupta Bedd,(Fabaceae) is used in Indian folk medicine to treat cancer.
Angiogenesis is one of the crucial characteristics of cancer metastasis and is regulated by …
Angiogenesis is one of the crucial characteristics of cancer metastasis and is regulated by …
Potential Anti-Cancer Flavonoids Isolated From Caesalpinia bonduc Young Twigs and Leaves: Molecular Docking and In Silico Studies
FN Iheagwam, OO Ogunlana… - … and Biology Insights, 2019 - journals.sagepub.com
Tyrosine kinase (TK), vascular endothelial growth factor (VEGF), and matrix
metalloproteinases (MMP) are important cancer therapeutic target proteins. Based on …
metalloproteinases (MMP) are important cancer therapeutic target proteins. Based on …
[HTML][HTML] Pharmacophore modeling and molecular docking of flavonoid derivatives in abelmoschus manihot against human estrogen receptor alpha of breast cancer
R Patala, V Anggi - Sciences of Pharmacy, 2022 - etflin.com
Tamoxifen is the most commonly used anti-estrogen adjuvant therapy for estrogen receptor-
positive breast cancer. However, it is associated with an increased risk of some serious side …
positive breast cancer. However, it is associated with an increased risk of some serious side …