Application of natural products derivatization method in the design of targeted anticancer agents from 2000 to 2018

W Liu, Q Li, J Hu, H Wang, F Xu, Q Bian - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
A concept, natural products derivatization method (NPDM), was introduced to assess the
influence of natural products on the discovery of targeted anticancer agents. Subsequently …

Research advances on anti-cancer natural products

M Guo, J Jin, D Zhao, Z Rong, LQ Cao, AH Li… - Frontiers in …, 2022 - frontiersin.org
Malignant tumors seriously threaten people's health and life worldwide. Natural products,
with definite pharmacological effects and known chemical structures, present dual …

Natural products and synthetic analogs as a source of antitumor drugs

J Sharifi-Rad, A Ozleyen, T Boyunegmez Tumer… - Biomolecules, 2019 - mdpi.com
Cancer is a heterogeneous disease and one of the major issues of health concern,
especially for the public health system globally. Nature is a source of anticancer drugs with …

Anticancer drugs and potential anticancer leads inspired by natural products

P Kittakoop - Studies in natural products chemistry, 2015 - Elsevier
Natural products are recognized as a rich source of bioactive compounds for modern
medicine, particularly those for the treatment of cancer. Since natural products are …

New molecular entities and structure–activity relationships of drugs designed by the natural product derivatization method from 2010 to 2018

Q Cui, R Bian, F Xu, Q Li, W Wang, Q Bian - Studies in Natural Products …, 2021 - Elsevier
An important concept, the natural product derivatization method, was introduced and defined
to comprehensively evaluate the significance of natural product derivatization in the design …

Exploring anticancer properties of the phytoconstituents and comparative analysis of their chemical space parameters with USFDA‐approved synthetic anticancer …

S Thapliyal, R Vishnoi, Y Murti, R Kumar… - Chemical Biology & …, 2024 - Wiley Online Library
The present review article thoroughly analyses natural products and their derived
phytoconstituents as a rich source of plausible anticancer drugs. The study thoroughly …

Exploring the therapeutic effects of synthetic, semi-synthetic and naturally derived compounds against cancer

L Feng, J Gu, Y Yang, B Yang, R Shi - Frontiers in Pharmacology, 2023 - frontiersin.org
There are serious challenges in the treatment of cancer, which can sometimes be
lifethreatening. Indeed, natural compounds or naturally-derived compounds have been …

Natural products as anticancer agents: current status and future perspectives

A Naeem, P Hu, M Yang, J Zhang, Y Liu, W Zhu… - Molecules, 2022 - mdpi.com
Natural products have been an invaluable and useful source of anticancer agents over the
years. Several compounds have been synthesized from natural products by modifying their …

Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation

WH Talib, I Alsalahat, S Daoud, RF Abutayeh… - Molecules, 2020 - mdpi.com
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Evaluation of the target-specific therapeutic potential of herbal compounds for the treatment of cancer

S Upreti, SC Pandey, I Bisht, M Samant - Molecular Diversity, 2022 - Springer
Cancer is among one of the most fatal diseases leading to millions of death around the
globe. Chemotherapy is the most popular conventional approach for the treatment of cancer …