Chondroprotective and anti-inflammatory effects of sesamin
T Phitak, P Pothacharoen, J Settakorn, W Poompimol… - Phytochemistry, 2012 - Elsevier
Osteoarthritis (OA) is a major disability of elderly people. Sesamin is the main compound in
Sesamun indicum Linn., and it has an anti-inflammatory effect by specifically inhibiting Δ5 …
Sesamun indicum Linn., and it has an anti-inflammatory effect by specifically inhibiting Δ5 …
Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status
M Hemshekhar, RM Thushara, S Jnaneshwari… - European journal of …, 2013 - Springer
Purpose The dietary sesamol is one of the important constituent of sesame seed that has
been mainly claimed to combat cardiovascular disease and diabetes, which are the major …
been mainly claimed to combat cardiovascular disease and diabetes, which are the major …
[HTML][HTML] Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway
P Kong, G Chen, A Jiang, Y Wang, C Song, J Zhuang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-
inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory …
inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory …
A randomized, triple‐blind, placebo‐controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical …
Inflammation is one of the main characteristics of rheumatoid arthritis. Based on the
antiinflammatory properties of sesame, this study was conducted to evaluate the sesamin …
antiinflammatory properties of sesame, this study was conducted to evaluate the sesamin …
Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells
YC Lu, T Jayakumar, YF Duann, YC Chou… - Journal of agricultural …, 2011 - ACS Publications
Overexpression of matrix metalloproteinases (MMPs) is a major pathological factor causing
cartilage destruction in osteoarthritis (OA). This study aimed to investigate the effects and …
cartilage destruction in osteoarthritis (OA). This study aimed to investigate the effects and …
Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc
K Li, Y Li, B Xu, L Mao, J Zhao - Connective tissue research, 2016 - Taylor & Francis
Intervertebral disc (IVD) degeneration contributes to most spinal degenerative diseases,
while treatment inhibiting IVD degeneration is still in the experimental stage. Sesamin, a …
while treatment inhibiting IVD degeneration is still in the experimental stage. Sesamin, a …
Sesamin protects the femoral head from osteonecrosis by inhibiting ROS-induced osteoblast apoptosis in rat model
S Deng, JL Zhou, HS Fang, ZG Nie, S Chen… - Frontiers in …, 2018 - frontiersin.org
Glucocorticoids intake has become the most common pathogenic factor for osteonecrosis of
the femoral head (ONFH). Annually, tens of millions of patients suffer from pain related to …
the femoral head (ONFH). Annually, tens of millions of patients suffer from pain related to …
Effects of sesamin on primary human synovial fibroblasts and SW982 cell line induced by tumor necrosis factor-alpha as a synovitis-like model
M Khansai, T Phitak, J Klangjorhor, S Udomrak… - … and alternative medicine, 2017 - Springer
Background Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic
synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation …
synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation …
Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways
O Wanachewin, K Boonmaleerat… - … and alternative medicine, 2012 - Springer
Background Osteoporosis is a worldwide health problem predominantly affecting post-
menopausal women. Therapies aimed at increasing bone mass in osteoporetic patients lag …
menopausal women. Therapies aimed at increasing bone mass in osteoporetic patients lag …
Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids
X Lin, T Lin, X Wang, J He, X Gao, S Lyu, Q Wang… - Phytomedicine, 2023 - Elsevier
Background Rheumatoid arthritis (RA) is an autoimmune disease known as a leading cause
of disability with considerable mortality. Developing alternative drugs and targets for RA …
of disability with considerable mortality. Developing alternative drugs and targets for RA …