The present review provides the state of the art of the current knowledge concerning gap
junctional channels and their roles in liver functioning. In the first part, we summarize some …

In the normal liver, cells interact closely through gap junctions. By providing a pathway for
the trafficking of low molecular mass molecules, these channels contribute to tissue …

Gap junctions are a specialized group of cell-to-cell junctions that mediate direct intercellular
communication between cells. They arise from the interaction of two hemichannels of …

Direct communication between hepatocytes, mediated by gap junctions, constitutes a major
regulatory platform in the control of liver homeostasis, ranging from hepatocellular …

Because of their critical role as goalkeepers of hepatic homeostasis, gap junctions are
frequent targets in liver disease. This concept has been demonstrated on many occasions in …

The hepatocytes in the mature normal liver are tightly coupled through gap junctions, except
during compensatory hyperplasia (regeneration) after partial hepatectomy when the gap …

Hepatocytes were isolated from wild-type and connexin32-deficient (Cx32-deficient) mice.
Pairs of cells were chosen to study the electrical properties of gap junction channels using …

Gap junction channels allow intercellular exchange of ions and small molecules between
adjacent cells. Such communication coordinates cellular and organ function in tissues …

In a recent review article,“Risk Assessment for Possible Carcinogens: A Critical Look”(1), Dr.
Emmanuel Farber states,“There is a developing speculation that agents or circumstances …

Hepatocytes and other digestive epithelia exchange second messengers and coordinate
their functions by communicating through gap junctions. However, little is known about …