Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Abstract Purpose Lamins A/C, a major component of the nuclear lamina, play key roles in
maintaining nuclear integrity, regulation of gene expression, cell proliferation and apoptosis …

Morphological changes in the size and shape of the nucleus are highly prevalent in cancer,
but the underlying molecular mechanisms and the functional relevance remain poorly …

Through advances in technology, the genetic basis of cancer has been investigated at the
genomic level, and many fundamental questions have begun to be addressed. Among …

Abstract Lamin A/C (LMNA), lamin B1 (LMNB1) and lamin B receptor (LBR) have key roles
in nuclear structural integrity and chromosomal stability. In this study, we have studied the …

Lamins are multifunctional proteins that are often aberrantly expressed or localized in
tumours. Here, we endeavour to assess their uses as cancer biomarkers: to diagnose …

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …

Lamins are the key components of the nuclear lamina and by virtue of their interactions with
chromatin and binding partners act as regulators of cell proliferation and differentiation. Of …

Cell migration through solid tissue often involves large contortions of the nucleus, but
biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both …

Cell motility plays a critical role in many physiological and pathological settings, ranging
from wound healing to cancer metastasis. While cell migration on 2-dimensional (2-D) …