Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …

Major depressive disorder (MDD) contributes to a significant worldwide disease burden,
expected to be second only to heart disease by 2050. However, accurate diagnosis has …

Background Current practice for selecting pharmacological and non-pharmacological
antidepressant treatments has yielded low response and remission rates in Major …

Currently, the diagnosis of major depressive disorder (MDD) mainly relies on clinical
examination and subjective evaluation of depressive symptoms. There is no non-invasive …

Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of
symptomatic criteria alone. It would be of great help when specific biomarkers for various …

Importance Biological psychiatry aims to understand mental disorders in terms of altered
neurobiological pathways. However, for one of the most prevalent and disabling mental …

Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …

A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

The pathophysiology of major depressive disorder (MDD) remains elusive, and there is no
established biochemical marker used in the daily clinical setting. This situation may result in …