Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to
silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable …

Oligonucleotides, including antisense oligonucleotides and siRNA, are promising
therapeutic agents against a variety of diseases. Effective delivery of these molecules is …

Introduction: The use of aptamers, antisense technology and RNA interference has allowed
nucleic acids to be considered as promising alternatives to classical drugs. However …

Background The potential use of nucleic acids as therapeutic drugs has triggered the quest
for oligonucleotide conjugates with enhanced cellular permeability. To this end, the …

Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as
powerful therapeutic compounds for targeting mRNAs and inducing their degradation …

Introduction: Oligonucleotide therapeutics have the potential to change the way disease is
treated due to their ability to modulate gene expression of any therapeutic target in a highly …

Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have
been recognized as powerful tools that can treat a broad spectrum of diseases. The …

Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and
RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the …

Synthetic vectors for therapeutic nucleic acid delivery are currently competing significantly
with their viral counter parts due to their reduced immunogenicity, large payload capacity …

From the early days of research on RNA biology and biochemistry, there was an interest to
utilize this knowledge and RNA itself for therapeutic applications. Today, we have a series of …