The functionality of DNA biomacromolecules has been widely excavated, as therapeutic
drugs, carriers, and functionalized modification derivatives. In this study, we developed a …

Introduction RNA interference is a promising therapy in glioma treatment. However, the
application of RNA interference has been limited in glioma therapy by RNA instability and …

DNA nanostructures are promising biomaterials capable of arranging multiple functional
components with nanometer precision. Here, a double-bundle DNA tetrahedron is rationally …

We set out to design, synthesize, and optimize a DNA-minimal cage capable of
encapsulating oligonucleotide drugs to facilitate their delivery. Through rational design and …

Chemically modified DNA has been widely developed to fabricate various nucleic acid
nanostructures for biomedical applications. Herein, we report a facile strategy for …

Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy
against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting …

Using the DNA origami technique, we constructed a DNA nanodevice functionalized with
small interfering RNA (siRNA) within its inner cavity and the chemotherapeutic drug …

The fabrication of aptamers on DNA nanostructures through the DNA origami method has
shown great potential for in vitro and in vivo tumor targeting delivery. Herein, tetrahedral …

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting
siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have …

While siRNA is a potent therapeutic tool that can silence disease-causing mRNA, its in vivo
potency can be compromised due to the lack of target tissue specificity. Here, we report a …