Abstract Nitroxyl (HNO), one-electron reduced and protonated sibling of nitric oxide (NO), is
a potential regulator of cardiovascular functions. It produces positive inotropic, lusitropic …

Background Patients with diabetes are prone to develop cardiac hypertrophy and more
susceptible to myocardial ischemia–reperfusion (I/R) injury, which are concomitant with …

Protein kinase C (PKC) β2 is preferably overexpressed in the diabetic myocardium, which
induces cardiomyocyte hypertrophy and contributes to diabetic cardiomyopathy, but the …

Background—Nitroxyl (HNO), a redox congener of nitric oxide (NO·), is a novel regulator of
cardiovascular function, combining concomitant positive inotropic, lusitropic, and vasodilator …

Diabetes, one of the major risk factors of metabolic syndrome culminates in the development
of Ischemic Heart Disease (IHD). Refined diets that lack micronutrients, mainly trivalent …

Diabetic cardiomyopathy (DCM) is a severe complication of diabetes mellitus that is
characterized by aberrant myocardial structure and function and is the primary cause of …

Objective: Nitric oxide synthase (NOS)-derived nitric oxide (NO) production is regulated
posttranslationally through enzyme's inhibitory interaction with the caveolar coat protein …

Background: Oxidative stress inducing hyperglycemia and high glucose play an important
role in the development of cardiac fibrosis associated with diabetic cardiomyopathy. The …

Background—In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an
isoform-specific manner, which is critically dependent on their cellular and subcellular …

Peroxynitrite (ONOO−) contributes to coronary microvascular dysfunction in diabetes
mellitus (DM). We hypothesized that in DM, ONOO− interferes with the function of coronary …