Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway
Y Ding, L Zhao, H Mei, SL Zhang, ZH Huang… - European Journal of …, 2008 - Elsevier
Emodin, 1, 3, 8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the
roots of Rheum officinale Baill that has been used to treat many diseases in digestive system …
roots of Rheum officinale Baill that has been used to treat many diseases in digestive system …
[HTML][HTML] Emodin protects against concanavalin A-induced hepatitis in mice through inhibiting activation of the p38 MAPK-NF-κB signaling pathway
J Xue, F Chen, J Wang, S Wu, M Zheng… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: To investigate the effects of emodin on concanavalin A (Con A)-induced
hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: A …
hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: A …
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis
Aim The effects of diosmin (DS), pentoxifylline (PTX) and their combination on inflammatory
response, oxidant/antioxidant balance, cytoglobin and cirrhotic reaction during bile duct …
response, oxidant/antioxidant balance, cytoglobin and cirrhotic reaction during bile duct …
The effect of emodin on liver disease--comprehensive advances in molecular mechanisms
N Hu, J Liu, X Xue, Y Li - European journal of pharmacology, 2020 - Elsevier
Liver injury could be caused by a variety of causes, including alcohol, drug poisoning,
autoimmune overreaction, etc. In the period of liver injury, hepatic stellate cells (HSCs) will …
autoimmune overreaction, etc. In the period of liver injury, hepatic stellate cells (HSCs) will …
Emodin attenuates acetaminophen-induced hepatotoxicity via the cGAS-STING pathway
P Shen, L Han, G Chen, Z Cheng, Q Liu - Inflammation, 2022 - Springer
Emodin is a natural bioactive compound from traditional Chinese herbs that exerts anti-
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …
Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway
M Abd-Elbaset, ESA Arafa, GA El Sherbiny… - Naunyn-Schmiedeberg's …, 2017 - Springer
Oxidative and nitrosative stress-induced endothelial cell damage play an essential role in
the pathogenesis of hepatic ischemia-reperfusion (IR) injury. IR is associated with reduced …
the pathogenesis of hepatic ischemia-reperfusion (IR) injury. IR is associated with reduced …
Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS
ST Devkar, AD Kandhare, AA Zanwar… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Overdose of acetaminophen (APAP) is common in humans and is often associated
with hepatic damage. Withania somnifera (L.) Dunal (Solanaceae) shows multiple …
with hepatic damage. Withania somnifera (L.) Dunal (Solanaceae) shows multiple …
Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism
Present study, was an effort to scrutinize the molecular and biochemical role of ibuprofen
and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single …
and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single …
Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation
Z Tan, M Luo, J Yang, Y Cheng, J Huang… - Journal of Pharmacy …, 2016 - academic.oup.com
Objectives Chlorogenic acid (CGA) is one of the most widely consumed polyphenols in diets
and is recognized to be a natural hepatoprotective agent. Here, we evaluated the protective …
and is recognized to be a natural hepatoprotective agent. Here, we evaluated the protective …
[HTML][HTML] Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation
WY Yao, YF Zhou, AH Qian… - Molecular …, 2015 - spandidos-publications.com
Severe acute pancreatitis (SAP) accounts for up to 20% of acute pancreatitis (AP) cases.
The absence of effective treatment options has resulted in a high rate of morbidity and …
The absence of effective treatment options has resulted in a high rate of morbidity and …