THE PAST decade has witnessed an upsurge in our understanding of the hypothalamic
regulation of appetite. Expression of appetite or the motivational drive toward an energy …

Obesity, a condition already at epidemic proportions in the developed world, is largely
attributable to an indulgent lifestyle. Biologically we feel hunger more acutely than feeling; …

The anorexigenic hormone leptin plays an important role in the control of food intake and
feeding-related behavior, for an important part through its action in the hypothalamus. The …

Since its discovery, leptin (a 167‐amino acid product of the OB gene) has quickly moved to
the forefront as an important hormone for regulation of energy balance. It closes a feedback …

Discovery of the leptin receptor and its downstream peptidergic pathways has reconfirmed
the crucial role of the hypothalamus in the regulation of food intake and energy balance …

Eating disorders are a group of disease states including anorexia nervosa, bulimia nervosa
and binge eating on one end as well as episodic or chronic overeating resulting in obesity at …

The adipocyte-derived hormone leptin is a peripheral signal that informs the brain about the
metabolic status of an organism. Although traditionally viewed as an appetite-suppressing …

Body adiposity is known to be carefully regulated and to remain relatively stable for long
periods of time in most mammalian species. This review summarizes old and recent data …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …

A chronic minor imbalance between energy intake and energy expenditure may lead to
obesity. Both lean and obese subjects eventually reach energy balance and their body …