Telomere dysfunction in ageing and age-related diseases
Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …
dysfunction. Telomere shortening and damage are recognized causes of cellular …
Telomeres and cell senescence-size matters not
S Victorelli, JF Passos - EBioMedicine, 2017 - thelancet.com
Telomeres are protective structures present at the ends of linear chromosomes that are
important in preventing genome instability. Telomeres shorten as a result of cellular …
important in preventing genome instability. Telomeres shorten as a result of cellular …
[PDF][PDF] Telomeres: history, health, and hallmarks of aging
The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …
Telomeres and aging
G Aubert, PM Lansdorp - Physiological reviews, 2008 - journals.physiology.org
Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …
Telomere-associated aging disorders
PL Opresko, JW Shay - Ageing research reviews, 2017 - Elsevier
Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Several monogenic inherited diseases that display features of human …
chromosome ends. Several monogenic inherited diseases that display features of human …
Telomere dysfunction in aging and cancer
D Gilley, H Tanaka, BS Herbert - The international journal of biochemistry & …, 2005 - Elsevier
Telomeres are unique DNA-protein structures that contain noncoding TTAGGG repeats and
telomere-associated proteins. These specialized structures are essential for maintaining …
telomere-associated proteins. These specialized structures are essential for maintaining …
Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …
Telomeres as biomarkers for ageing and age-related diseases
T Zglinicki, CM Martin-Ruiz - Current molecular medicine, 2005 - ingentaconnect.com
Telomeres in telomerase-negative cells shorten during DNA replication in vitro due to
numerous causes including the inability of DNA polymerases to fully copy the lagging …
numerous causes including the inability of DNA polymerases to fully copy the lagging …
Telomere biology and human phenotype
KJ Turner, V Vasu, DK Griffin - Cells, 2019 - mdpi.com
Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …
function to maintain genome stability. The length of telomeres is known to shorten with each …
Cellular senescence, cancer and aging: the telomere connection
J Campisi, S Kim, CS Lim, M Rubio - Experimental gerontology, 2001 - Elsevier
Telomeres are the repetitive DNA sequences and specialized proteins that form the
distinctive structure that caps the ends of linear chromosomes. Telomeres allow cells to …
distinctive structure that caps the ends of linear chromosomes. Telomeres allow cells to …