[HTML][HTML] The ABCs of membrane transporters in health and disease (SLC series): introduction

MA Hediger, B Clémençon, RE Burrier… - Molecular aspects of …, 2013 - Elsevier
The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction

MA Hediger, MF Romero, JB Peng, A Rolfs… - Pflügers Archiv, 2004 - Springer
Abstract The Human Genome Organisation (HUGO) Nomenclature Committee Database
provides a list of transporter families of the solute carrier (SLC) gene series (see http://www …

Analysis and update of the human solute carrier (SLC) gene superfamily

L He, K Vasiliou, DW Nebert - Human genomics, 2009 - Springer
The solute-carrier gene (SLC) superfamily encodes membrane-bound transporters. The
SLC superfamily comprises 55 gene families having at least 362 putatively functional protein …

Classification systems of secondary active transporters

E Perland, R Fredriksson - Trends in pharmacological sciences, 2017 - cell.com
Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as
they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across …

[HTML][HTML] The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families

R Fredriksson, KJV Nordström, O Stephansson… - FEBS letters, 2008 - Elsevier
Solute carriers (SLCs) is the largest group of transporters, embracing transporters for
inorganic ions, amino acids, neurotransmitters, sugars, purines and fatty acids among other …

[PDF][PDF] A call for systematic research on solute carriers

A Cesar-Razquin, B Snijder, T Frappier-Brinton… - Cell, 2015 - cell.com
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

Solute carrier transporters as potential targets for the treatment of metabolic disease

T Schumann, J König, C Henke, DM Willmes… - Pharmacological …, 2020 - ASPET
The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

SLC transporters as therapeutic targets: emerging opportunities

L Lin, SW Yee, RB Kim, KM Giacomini - Nature reviews Drug discovery, 2015 - nature.com
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

SLC transporters: structure, function, and drug discovery

C Colas, PMU Ung, A Schlessinger - Medchemcomm, 2016 - pubs.rsc.org
The human solute carrier (SLC) transporters are important targets for drug development.
Structure-based drug discovery for SLC transporters requires the description of their …

SLC family transporters

X Liu - Drug Transporters in Drug Disposition, Effects and …, 2019 - Springer
Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …