Small molecule inhibitors are prime reagents for studies in microtubule cytoskeleton
research, being applicable across a range of biological models and not requiring genetic …

Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca
alkaloids, are widely used in cell biology research and as clinical anticancer drugs …

Optical methods to modulate microtubule dynamics show promise for reaching the micron‐
and millisecond‐scale resolution needed to decrypt the roles of the cytoskeleton in biology …

Photoremovable protecting groups added to bioactive molecules provide spatial and
temporal control of the biological effects. We present synthesis and characterization of the …

Photoswitchable reagents are powerful tools for high-precision studies in cell biology. When
these reagents are globally administered yet locally photoactivated in two-dimensional (2D) …

Optically controlled chemical reagents, termed" photopharmaceuticals," are powerful tools
for precise spatiotemporal control of proteins particularly when genetic methods, such as …

Microtubules are key components of the eukaryotic cytoskeleton with essential roles in cell
division, intercellular transport, cell morphology, motility, and signal transduction. They are …

Microtubules are cytoskeletal polymers that separate chromosomes during mitosis and
serve as rails for intracellular transport and organelle positioning. Manipulation of …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used
for the treatment of cancer. Despite the importance of MSAs for medical applications and …