[HTML][HTML] Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive …
H He, L Wang, Y Qiao, B Yang, D Yin, M He - Redox Biology, 2021 - Elsevier
Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model
X Li, J Liang, L Qu, S Liu, A Qin, H Liu, T Wang… - Chemico-Biological …, 2022 - Elsevier
Doxorubicin (DOX) is an effective antitumor drug; however, but its clinical application is
seriously limited by the cardiotoxicity induced by its use. Recent studies have found that …
seriously limited by the cardiotoxicity induced by its use. Recent studies have found that …
Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway
H Chen, J Zhu, Y Le, J Pan, Y Liu, Z Liu, C Wang… - Phytomedicine, 2022 - Elsevier
Background Doxorubicin-induced cardiotoxicity (DIC) limits the clinical application of the
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …
drug in treatment of cancers and imposes a severe health burden on the patients. Therefore …
Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis
Abstract Aloe-emodin (AE), a novel ferroptosis inhibitor, alleviates the doxorubicin (DOX)-
induced cardiotoxicity in H9c2 rat cardiomyocytes. The inhibition of ferroptosis and the …
induced cardiotoxicity in H9c2 rat cardiomyocytes. The inhibition of ferroptosis and the …
The Imbalance of p53–Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin‐Challenged Cardiomyocytes
J Pan, W Xiong, A Zhang, H Zhang, H Lin… - Advanced …, 2023 - Wiley Online Library
Abstract Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer
patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in …
patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in …
[HTML][HTML] Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling
Y Chen, X Guo, Y Zeng, X Mo, S Hong, H He… - Free Radical Biology …, 2023 - Elsevier
High levels of circulating catecholamines cause cardiac injury, pathological remodeling, and
heart failure, but the underlying mechanisms remain elusive. Here we provide both in vitro …
heart failure, but the underlying mechanisms remain elusive. Here we provide both in vitro …
[HTML][HTML] Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition
Y Liu, L Zeng, Y Yang, C Chen, D Wang… - Cell death & disease, 2020 - nature.com
In this study, we first established the doxorubicin-induced cardiotoxicity (DIC) model with
C57BL/6 mice and confirmed cardiac dysfunction with transthoracic echocardiography …
C57BL/6 mice and confirmed cardiac dysfunction with transthoracic echocardiography …
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression
X Sun, P Sun, D Zhen, X Xu, L Yang, D Fu… - Toxicology and Applied …, 2022 - Elsevier
Doxorubicin (Dox) is a high-efficiency agent for cancer therapy. However, it causes
cardiotoxicity which limits its clinical application. Despite more efforts has been made to …
cardiotoxicity which limits its clinical application. Despite more efforts has been made to …
Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway
Y Jia, D Zuo, Z Li, H Liu, Z Dai, J Cai… - Chemical and …, 2014 - jstage.jst.go.jp
Doxorubicin (DOX) is a widely used antitumor drug whose application is seriously limited by
its cardiotoxicity. Mitochondria-mediated cardiomyocyte apoptosis plays a critical role in …
its cardiotoxicity. Mitochondria-mediated cardiomyocyte apoptosis plays a critical role in …
Activation of p62-NRF2 axis protects against doxorubicin-induced ferroptosis in cardiomyocytes: a novel role and molecular mechanism of resveratrol
W Yu, C Chen, C Xu, D Xie, Q Wang, W Liu… - The American Journal …, 2022 - World Scientific
Doxorubicin (DOX) is a most common anthracycline chemotherapeutic agent; however, its
clinical efficacy is limited due to its severe and irreversible cardiotoxicity. Ferroptosis …
clinical efficacy is limited due to its severe and irreversible cardiotoxicity. Ferroptosis …